Sino Biological/Anti-ACVR2B Antibody, Rabbit Polyclonal/10229-T20
商品编号：
10229-T20
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Anti-ACVR2B Antibody, Rabbit Polyclonal General Information
Product name
Anti-ACVR2B Antibody, Rabbit Polyclonal
Validated applications
ELISA,IP
Species reactivity
Reacts with: Human
Specificity
Human ACVR2B
Immunogen
Recombinant Human ACVR2BProtein (Catalog#10229-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ACVR2B(rh ACVR2B ; Catalog#10229-H08H; NP_001097.2; Met1-Thr134). ACVR2Bspecific IgG was purified by Human ACVR2Baffinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-ACVR2B Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:5000-1:10000 |
| IP | 0.5-2 μL/mg of lysate |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-ACVR2B Antibody, Rabbit Polyclonal Images
-HD09MA0901-IP.png)
ACVR2B was immunoprecipitated using:
Lane A:0.5 mg 293T Whole Cell Lysate
2 µL anti-ACVR2B rabbit polyclonal antibody and 15 μl of50 %Protein G agarose.
Primary antibody:
Anti-ACVR2B rabbit polyclonal antibody,at 1:100 dilution
Secondary antibody:
Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution
Developed using the odssey technique.
Performed under reducing conditions.
Predicted band size: 85 kDa
Observed band size: 85 kDa
Anti-ACVR2B Antibody, Rabbit Polyclonal: Synonyms
Anti-Activin RIIB Antibody; Anti-ActR-IIB Antibody; Anti-ACTRIIB Antibody; Anti-HTX4 Antibody
ACVR2B Background Information
ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Full Name
activin A receptor, type IIB
References
- Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
- Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
- Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
- Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
- A validated, sensitive electrophoretic method for the detection of activin receptor type II-Fc fusion proteins in human bloodAuthorMartin, L;Zouhiri, N;Audran, M;Marchand, A;Year2018JournalDrug Test AnalPubMed ID: 29499588FoldedExpand
- Updated protocols for the detection of Sotatercept and Luspatercept in human serumAuthorReichel, C;Gmeiner, G;Walpurgis, K;Thevis, M;Year2018JournalDrug Test AnalPubMed ID: 30203930FoldedExpand
Recombinant Antibody Production Service
High-throughput Recombinant Antibody Production
Large-scale Antibody Production
Antibody Development Service
Rabbit MAb Production Service
Mouse MAb Production Service
Rabbit PAb Production Service
Phospho-Specific Antibody
Anti-Idiotype Antibody
Fast Antibody Development Service
Mouse MAb
Rabbit PAb
More Antibody Production Service
Hybridoma Antibody Production
Chimeric Antibody
Antibody Fragment
Bispecific Antibody
We also have Immunoassay Service. Click to see more.
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
