Sino Biological/IL17/IL17a中和抗体/1/12047-M237
商品编号：
12047-M237
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL17 / IL17a Neutralizing Antibody General Information
Product name
IL17 / IL17a Neutralizing Antibody
Validated applications
Neutralization
Species reactivity
Reacts with: Human
Specificity
Human IL17Has cross-reactivity in ELISA withCanine IL17A (Catalog # 70102-DNAE)No cross-reactivity in ELISA withMouse IL17A (Catalog # 51065-MNAE)
Immunogen
Recombinant Human IL17 / IL17a protein (Catalog#12047-HNAE)
Preparation
This antibody was obtained from a mouse immunized with purified, recombinant Human IL17 / IL17a (rHuman IL17 / IL17a; Catalog#12047-HNAE; Q16552; Ile20-Ala155) and was produced using recombinant antibody technology.
Source
Monoclonal Mouse IgG1 Clone #M237
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Endotoxin
Please contact us for more information.
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
IL17 / IL17a Neutralizing Antibody Validated Applications
Notes
| Block： | In a functional ELISA which immobilized recombinant Human IL17a (Catalog# 12047-HNAE) at 1μg/mL (100 µL/well) in the plate, the Rabbit anti-Human IL17a Monoclonal Antibody (Catalog# 12047-M237) can block the binding of 0.5μg/mL of biotinylated recombinant Human IL17Ra (Catalog# 10895-H03H-B) to human IL17a,the EC50 is 0.60 μg/mL. |
| Neutralization： | The neutralization activity of IL17a Neutralizing Antibody is measured by its ability to neutralize IL6 secretion induced by human IL17a (12047-HNAE) in the HFF human foreskin fibroblast. The Neutralization Titer (IC50) is typically 0.23-0.94 µg/mL in the presence of 50 ng/mL Recombinant Human IL17a (Catalog # 12047-HNAE) . |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
IL17 / IL17a Neutralizing Antibody Images
The ability of Human IL-17a Neutralizing Mouse mAb to inhibit IL-17A-induced IL-6 production was analyzed. IL6 secretion in the HFF human foreskin fibroblast induced by 50 ng/mL of Recombinant Human IL17a (12047-HNAE) is neutralized by increasing concentrations of mouse anti-Human IL17a neutralizing Monoclonal Antibody (Catalog # 12047-M237), as measured by IL6 Quantitative ELISA Kit (Catalog # KIT10395).The IC50 is typically 0.23-0.94 μg/mL.
IL17 / IL17a Neutralizing Antibody: Synonyms
Anti-CTLA-8 Antibody; Anti-CTLA8 Antibody; Anti-IL-17 Antibody; Anti-IL-17A Antibody; Anti-IL17 Antibody
IL17 Background Information
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interleukin 17A
Research Areas
- Neuroinflammation
Related Pathways
IL12 signaling pathway
IL17 signaling pathway
References
- Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
- Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
- Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
- Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
- Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson"s DiseaseAuthorSommer, A;Maxreiter, F;Krach, F;Fadler, T;Grosch, J;Maroni, M;Graef, D;Eberhardt, E;Riemenschneider, MJ;Yeo, GW;Kohl, Z;Xiang, W;Gage, FH;Winkler, J;Prots, I;Winner, B;Year2018JournalCell Stem CellApplicationcell-basedPubMed ID: 29979986FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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