Sino Biological/IL-17R / IL-17RA / CD217 Neutralizing Antibody/1/10895-R004
商品编号：
10895-R004
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL-17R / IL-17RA / CD217 Neutralizing Antibody General Information
Product name
IL-17R / IL-17RA / CD217 Neutralizing Antibody
Validated applications
FCM,Neutralization
Species reactivity
Reacts with: Human
Specificity
Human IL17RAHas cross-reactivity in ELISA withCynomolgus IL17RA (Catalog # 90127-C02H)Mouse IL17RA (Catalog # 50328-M08H)
Immunogen
Recombinant Human IL-17R / IL-17RA / CD217 Protein (Catalog#10895-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-17R / IL-17RA / CD217 (rh IL-17R / IL-17RA / CD217; Catalog#10895-H08H; NP_055154.3; Met1-Trp320) and was produced using recombinant antibody technology.
Source
Monoclonal Rabbit IgG Clone #R004
Purification
Protein A
Formulation
0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Conjugate
Unconjugated
Endotoxin
< 3="">
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
IL-17R / IL-17RA / CD217 Neutralizing Antibody Validated Applications
| Application | Dilution |
|---|---|
| FCM | 0.5-2 μg/Test |
Notes
| Block： | In a functional ELISA which immobilized Human IL17a (Catalog# 12047-HNAS) at 1μg/mL (100 µL/well) in the plate, the Rabbit anti-Human IL17Ra Monoclonal Antibody (Catalog# 10895-R004) can block the binding of 0.5 μg/mL of biotinylated Human IL17Ra/Fc Chimera (Catalog# 10895-H03H-B) to human IL17a,the EC50 is 0.31 μg/mL. |
| Neutralization： | The neutralization activity of IL17Ra neutralizing antibody is measured by its ability to neutralize IL6 secretion induced by human IL17a (12047-HNAE) in the HFF human foreskin fibroblast .The Neutralization Titer (IC50) is typically 0.30-0.70 µg/mL in the presence of 50 ng/mL Recombinant Human IL17a (12047-HNAE) . |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
IL-17R / IL-17RA / CD217 Neutralizing Antibody Images
IL-17A-induced IL-6 production was Neutralized by Human IL17Ra Antibody. IL6 secretion in the HFF human foreskin fibroblast elicited by 50 ng/mL of Recombinant Human IL17a is neutralized by increasing concentrations of Human IL17Ra Monoclonal Antibody (Catalog # 10895-R004), as measured by IL6 Quantitative ELISA Kit (KIT10395). The IC50 is typically 0.30-0.70 μg/mL.
-R004-Purified-Granulocytes.png)
Flow cytometric analysis of Human IL17RA(CD217) expression on human whole blood granulocytes. Cells were stained with purified anti-Human IL17RA(CD217), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.
IL-17R / IL-17RA / CD217 Neutralizing Antibody: Synonyms
Anti-CANDF5 Antibody; Anti-CD217 Antibody; Anti-CDw217 Antibody; Anti-hIL-17R Antibody; Anti-IL-17RA Antibody; Anti-IL17R Antibody
IL17RA Background Information
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Full Name
interleukin 17 receptor A
Related Pathways
IL17 signaling pathway
References
- Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
- Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
- Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
- Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson"s DiseaseAuthorSommer, A;Maxreiter, F;Krach, F;Fadler, T;Grosch, J;Maroni, M;Graef, D;Eberhardt, E;Riemenschneider, MJ;Yeo, GW;Kohl, Z;Xiang, W;Gage, FH;Winkler, J;Prots, I;Winner, B;Year2018JournalCell Stem CellPubMed ID: 29979986FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
Recombinant Antibody Production Service
High-throughput Recombinant Antibody Production
Large-scale Antibody Production
Antibody Development Service
Rabbit MAb Production Service
Mouse MAb Production Service
Rabbit PAb Production Service
Phospho-Specific Antibody
Anti-Idiotype Antibody
Fast Antibody Development Service
Mouse MAb
Rabbit PAb
More Antibody Production Service
Hybridoma Antibody Production
Chimeric Antibody
Antibody Fragment
Bispecific Antibody
We also have Immunoassay Service. Click to see more.
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
