Sino Biological/Anti-PD-1 Antibody, Rabbit Polyclonal/1/50124-RP02
商品编号：
50124-RP02
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Anti-PD-1 Antibody, Rabbit Polyclonal General Information
Product name
Anti-PD-1 Antibody, Rabbit Polyclonal
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse PD-1
Immunogen
Recombinant Mouse PDCD1 protein (Catalog#50124-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse (rM PDCD1; Catalog#50124-M08H; Met 1-Gln 167; NP_032824.1). PDCD1 specific IgG was purified by mouse specific affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-PD-1 Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:1000-1:2000 |
| IHC-P | 1:500-1:2000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-PD-1 Antibody, Rabbit Polyclonal Images
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Immunochemical staining of mouse PDCD1 in mouse kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule.
Anti-PD-1 Antibody, Rabbit Polyclonal: Synonyms
Anti-Ly101 Antibody; Anti-PD-1 Antibody; Anti-Pdc1 Antibody
PD-1 Background Information
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
- Cancer Immunotherapy
- Co-inhibitory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Blockade: Blocking Antibodi
- Immune Checkpoint Blockade: PD1 / PDCD1 / CD2
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: IHC Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Proteins
- Immune Checkpoint Targets
- Immunotherapy
- PD1 / PDCD1 / CD279 Immune Checkpoint
- PD1 / PDCD1 / CD279 Immune Checkpoint Antibod
- PD1 / PDCD1 / CD279 Immune Checkpoint Protein
- Targeted Therapy
Full Name
programmed cell death 1
Research Areas
- ITIM/ITAM Immunoreceptors and Related Molecules
- Cancer Drug Targets
References
- James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
- Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
- del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
- Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
- Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in miceAuthorLijun Xiao1,2, Dimin Wang3, Pingchao Li1, Yi Jin1,2, Liqiang Feng1*, Caijun Sun1*, and Ling ChenYear2014JournalHuman Vaccines & ImmunotherapeuticsApplicationWBPubMed ID: 24326266FoldedExpand
- Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade ActivityAuthorZappasodi, R;Budhu, S;Hellmann, MD;Postow, MA;Senbabaoglu, Y;Manne, S;Gasmi, B;Liu, C;Zhong, H;Li, Y;Huang, AC;Hirschhorn-Cymerman, D;Panageas, KS;Wherry, EJ;Merghoub, T;Wolchok, JD;Year2018JournalCancer CellApplicationIFPubMed ID: 29894689FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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