Sino Biological/Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal/1/10837-R008
商品编号：
10837-R008
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal General Information
Product name
Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human SLAM/CD150No cross-reactivity in ELISA withHuman CD48 / BCM1 / BLAST1Human CD84 / SLAMF5Human 2B4 / NKR2B4 / CD244
Immunogen
Recombinant Human CD150 protein (Catalog#10837-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human SLAMF1 / CD150 (rh SLAMF1; Catalog#10837-H08H; NP_003028.1; Met 1-Pro 258).
Source
Monoclonal Rabbit IgG Clone #8
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:5000-1:10000 |
| IHC-P | 1:1000-1:4000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal Images
Immunochemical staining of human SLAMF1 in human tonsil with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SLAMF1 in human lymph node with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SLAMF1 in human appendix with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Recombinant Anti-SLAM/CD150 Antibody, Rabbit Monoclonal: Synonyms
Anti-CD150 Antibody; Anti-CDw150 Antibody; Anti-SLAM Antibody
SLAM/CD150 Background Information
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin"s lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of interferon γ (IFN-γ) in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.
Full Name
signaling lymphocytic activation molecule family member 1
Research Areas
- ITIM/ITAM Immunoreceptors and Related Molecules
References
- Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
- Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
- Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin"s lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
- Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
- SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophagesAuthorYurchenko, M;Skjesol, A;Ryan, L;Richard, GM;Kandasamy, RK;Wang, N;Terhorst, C;Husebye, H;Espevik, T;Year2018JournalJ. Cell Biol.ApplicationWBPubMed ID: SLAMF1 is required for TLR4-mediated TRAM-TRIFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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