Sino Biological/Anti-4-1BBL/TNFSF9 Antibody, Rabbit Polyclonal/1/50067-RP02
商品编号：
50067-RP02
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Anti-4-1BBL/TNFSF9 Antibody, Rabbit Polyclonal General Information
Product name
Anti-4-1BBL/TNFSF9 Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse 4-1BBL/TNFSF9
Immunogen
Recombinant Mouse TNFSF9 protein (Catalog#50067-M07H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse TNFSF9 / 4-1BBL extracellular domain (rM TNFSF9; Catalog#50067-M07H; Arg 104-Glu 309; NP_033430.1). TNFSF9 specific IgG was purified by mouse TNFSF9 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-4-1BBL/TNFSF9 Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:1000-1:2000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-4-1BBL/TNFSF9 Antibody, Rabbit Polyclonal: Synonyms
Anti-4-1BB-L Antibody; Anti-4-1BBL Antibody; Anti-AI848817 Antibody; Anti-Cd137l Antibody; Anti-Ly63l Antibody
4-1BBL/TNFSF9 Background Information
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
- Cancer Immunotherapy
- Co-stimulatory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: FCM Antibodies
- Immune Checkpoint Detection: ICC Antibodies
- Immune Checkpoint Targets
- Immunotherapy
- Targeted Therapy
Full Name
tumor necrosis factor (ligand) superfamily, member 9
Research Areas
- Cancer Drug Targets
References
- Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
- Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
- Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
- An adenoviral cancer vaccine co-encoding a tumor associated antigen together with secreted 4-1BBL leads to delayed tumor progressionAuthorRagonnaud, E;Andersson, AM;Pedersen, AE;Laursen, H;Holst, PJ;Year2016JournalVaccineApplicationWBPubMed ID: 27004934FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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