Sino Biological/Influenza A H1N1 Hemagglutinin / HA Antibody, Rabbit MAb/1/11684-R107
商品编号：
11684-R107
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Influenza A H1N1 Hemagglutinin / HA Antibody, Rabbit MAb General Information
Product name
Influenza A H1N1 Hemagglutinin / HA Antibody, Rabbit MAb
Validated applications
WB,ELISA,ELISA(Det)
Application notes
IHC, FCM, IF, IP et al. applications haven"t been validated.(Antibody"s applications haven"t been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
H1N1 Hemagglutinin/HANo cross-reactivity in ELISA withH1N1 (A/Brevig Mission/1/1918) HAH1N1 (A/New Caledonia/20/1999) HAH2N2 (A/Canada/720/2005) HAH3N2 (A/Brisbane/10/2007) HAH4N4 (A/mallard/Ohio/657/2002) HAH5N1 (A/Anhui/1/2005) HAH6N1 (A/northern shoveler/California/HKWF115/2007) HAH7N7 (A/chicken/Netherlands/1/03) HAH8N4 (A/pintail duck/Alberta/114/1979) HAH9N2 (A/Hong Kong/1073/99) HAH10N3 (A/duck/Hong Kong/786/1979) HAH11N2 (A/duck/Yangzhou/906/2002) HAH12N5 (A/green-winged teal/ALB/199/1991) HAH13N8 (A/black-headed gull/Netherlands/1/00) HAH15N8 (A/duck/AUS/341/1983) HAH16N3 (A/black-headed gull/Sweden/5/99) HAInfluenza B (B/Florida/4/2006) HA
Immunogen
Recombinant Influenza A H1N1 HA / Hemagglutinin protein (Catalog#11684-V08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Influenza A H1N1 HA / Hemagglutinin (Catalog#11684-V08H; ABD77675.1; Met 1-Gln 528).
Source
Monoclonal Rabbit IgG Clone #107
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Influenza A H1N1 Hemagglutinin / HA Antibody, Rabbit MAb Validated Applications
| Application | Dilution |
|---|---|
| WB | his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect H1N1 (A/Puerto Rico/8/1934) HA in WB. Using a DAB detection system, the detection limit for H1N1 (A/Puerto Rico/8/1934) HA is approximately 5 ng/lane under non-reducing conditions and reducing conditions. |
| ELISA | 1:5000-1:10000 |
| ELISA(Det) | 1:1000-1:10000 |
Notes
| ELISA(Det)： | This antibody will detect Influenza A H1N1 HA / Hemagglutinin in ELISA pair set (Catalog: # SEKA11684). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11684-R016). |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Hemagglutinin/HA Background Information
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells" sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
Full Name
Harvey rat sarcoma viral oncogene homolog
References
- White JM, Hoffman LR, Arevalo JH, et al. Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin. In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.1997
- Suzuki Y.Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol. Pharm. Bull. 2005.
- Senne DA, Panigrahy B, Kawaoka Y, et al. Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis. 1996
- Donald J. Benton,Influenza hemagglutinin membrane anchor,PNAS,2018
- Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effectAuthorXiao, S;Si, L;Tian, Z;Jiao, P;Fan, Z;Meng, K;Zhou, X;Wang, H;Xu, R;Han, X;Fu, G;Zhang, Y;Zhang, L;Zhou, D;Year2016JournalBiomaterialsApplicationHIPubMed ID: 26686050FoldedExpand
- Cell-Based Influenza A/H1N1pdm09 Vaccine Viruses Containing Chimeric Hemagglutinin with Improved Membrane Fusion AbilityAuthorKawahara, M;Wada, T;Momose, F;Nobusawa, E;Morikawa, Y;Year2020JournalVaccines (Basel)PubMed ID: 32825107FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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