Sino Biological/Anti-CD46 Antibody, Rabbit Polyclonal/1/12239-RP02-免疫在线蚂蚁淘旗下平台

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Sino Biological/Anti-CD46 Antibody, Rabbit Polyclonal/1/12239-RP02

商品编号： 12239-RP02

品牌： sinobiological

市场价： ¥0.00

美元价： 0.00

产地：美国(厂家直采)

公司：

产品分类：聚合物

公司分类： juhewu

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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Antibody Production Service

Anti-CD46 Antibody, Rabbit Polyclonal General Information

Product name

Anti-CD46 Antibody, Rabbit Polyclonal

Validated applications

WB,ELISA,IHC-P,IP

Species reactivity

Reacts with: Human

Specificity

Human CD46

Immunogen

Recombinant Human CD46 protein (Catalog#12239-H08H)

Preparation

Produced in rabbits immunized with purified, recombinant Human CD46 (rh CD46; Catalog#12239-H08H; EAW93471.1; Met 1-Asp 328). CD46 specific IgG was purified by Human CD46 affinity chromatography.

Source

Polyclonal Rabbit IgG

Purification

Protein A & Antigen Affinity

Formulation

0.2 μm filtered solution in PBS

Conjugate

Unconjugated

Form

Liquid

Shipping

This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD46 Antibody, Rabbit Polyclonal Validated Applications

Application	Dilution
WB	1:500-1:1000
ELISA	1:25000-1:50000
IHC-P	1:2500-1:15000
IP	1-2 μL/mg of lysate

Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD46 Antibody, Rabbit Polyclonal Images

Human CD46 Immunohistochemistry(IHC) 4494

Immunochemical staining of human CD46 in human placenta with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. Positive staining was localized to membrane of trophoblast.

Anti-CD46 rabbit polyclonal antibody at 1:500 dilution

Lane A: Hela Membrane Lysate

Lysates/proteins at 20 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:44 kDa

Observed band size:62 kDa

Human CD46 Immunoprecipitation(IP) 17660

CD46 was immunoprecipitated using:

Lane A:0.5 mg 293T Whole Cell Lysate

0.5 µL anti-CD46 rabbit polyclonal antibody and 15 μl of50 %Protein G agarose.

Primary antibody:

Anti-CD46 rabbit polyclonal antibody,at 1:1000 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 44 kDa

Observed band size: 62 kDa

Anti-CD46 Antibody, Rabbit Polyclonal: Synonyms

Anti-AHUS2 Antibody; Anti-MCP Antibody; Anti-MIC10 Antibody; Anti-TLX Antibody; Anti-TRA2.10 Antibody

CD46 Background Information

CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.

Full Name

CD46 molecule, complement regulatory protein

Related Pathways

Complement Activation Pathways

References

Lublin D.M., et al.,(1988), Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J. Exp. Med. 168:181-194.
Purcell D.F., et al., (1991), Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation.Immunogenetics 33:335-344.
Post T.W., et al.,(1991), Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype.J. Exp. Med. 174:93-102.

Anti-CD46 Antibody (PE)
【Mouse】【Monoclonal】【FCM】
12239-MM05-P
Anti-CD46 Antibody
【Mouse】【Monoclonal】【FCM,ICC/IF】
12239-MM05
Anti-CD46 Antibody (APC)
【Mouse】【Monoclonal】【FCM】
12239-MM05-A
Anti-CD46 Antibody
【Rabbit】【Monoclonal】【ELISA,IHC-P,ICC/IF】
12239-R001
Anti-CD46 Antibody
【Mouse】【Monoclonal】【ELISA,IHC-P】
12239-MM01
Anti-CD46 Antibody (FITC)
【Mouse】【Monoclonal】【FCM】
12239-MM05-F

Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: Immune targets in demyelinating neuropathies?
Author
Miyaji, K;Paul, F;Shahrizaila, N;Umapathi, T;Yuki, N;
Year
2014
Journal
J. Neuroimmunol.
PubMed ID: 25156074FoldedExpand

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品牌介绍

北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。

公司介绍

品牌分类

Elisa试剂盒试剂蛋白质试剂抗体试剂 Gene Reagent

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服务热线：4000-520-616

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官网：http://www.sinobiological.com/

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