Sino Biological/ELMO2 cDNA ORF Clone, Human, N-GFPSpark® tag/1/HG22013-ANG
商品编号：
HG22013-ANG
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
ELMO2 cDNA ORF Clone, Human, N-GFPSpark® tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_182764.1
RefSeq ORF Size
2892 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 2709T/C not causing the amino acid variation.
Description
Full length Clone DNA of Human engulfment and cell motility 2 with N terminal GFPSpark tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-N-GFPSpark®
Restriction Sites
KpnI + XbaI(6kb+2.89kb)
Tag Sequence
GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
ELMO2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
More Information About ELMO2
Entrez Gene ID
63916
ELMO2 cDNA ORF Clone, Human, N-GFPSpark® tag: Validated Images
ELMO2 cDNA ORF Clone, Human, N-GFPSpark® tag: Synonyms
ELMO2 cDNA ORF Clone, Human
ELMO2 Background Information
Engulfment and cell motility (ELMO) proteins bind to Dock180, a guanine nucleotide exchange factor (GEF) of the Rac family, and regulate GEF activity. The resultant ELMO/Dock180/Rac module regulates cytoskeletal reorganization responsible for the engulfment of apoptotic cells, cell migration, and neurite extension. ELMO2 belongs to a family of scaffold proteins involved in phagocytosis and cell motility. ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartite ERI complexes. These complexes are involved in promoting β1 integrin-dependent directional migration in undifferentiated epidermal keratinocytes. ELMO2 and ILK have also separately been implicated in microtubule regulation at integrin-containing focal adhesions. During differentiation, epidermal keratinocytes cease to express integrins, but ERI complexes persist.
References
- Sato Y, et al. (2019) Comparative gene expression analysis of the engulfment and cell motility (elmo) protein family in the mouse brain. Gene Expr Patterns 34 119070.
- Katoh H, et al. (2006) Differential distribution of elmo1 and elmo2 mrnas in the developing mouse brain. Brain Res 1073-1074 103-108.
- Jackson BC, et al. (2015) An elmo2-rhog-ilk network modulates microtubule dynamics. Mol Biol Cell 26 (14): 2712-2725.
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- Identification of lncRNA-associated differential subnetworks in oesophageal squamous cell carcinoma by differential co-expression analysisAuthorLiu, W;Gan, CY;Wang, W;Liao, LD;Li, CQ;Xu, LY;Li, EM;Year2020JournalJ. Cell. Mol. Med.ApplicationexpressionPubMed ID: 32164040FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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