Sino Biological/CD18 cDNA ORF Clone, Mouse, untagged/1/MG50359-UT
商品编号：
MG50359-UT
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
CD18 cDNA ORF Clone, Mouse, untagged: General Information
Gene
Species
Mouse
NCBI Ref Seq
NM_008404.4
RefSeq ORF Size
2313 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Mouse integrin beta 2.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Restriction Sites
KpnI + NotI (6.1kb + 2.31kb)
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
CD18 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
CD18 cDNA ORF Clone, Mouse, untagged: Validated Images
CD18 cDNA ORF Clone, Mouse, untagged: Synonyms
2000000 cDNA ORF Clone, Mouse; AI528527 cDNA ORF Clone, Mouse; Cd18 cDNA ORF Clone, Mouse; LAD cDNA ORF Clone, Mouse; LCAMB cDNA ORF Clone, Mouse; Lfa1 cDNA ORF Clone, Mouse; MF17 cDNA ORF Clone, Mouse
CD18 Background Information
ITGB2 (Integrin Subunit Beta 2) is a Protein Coding gene. This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. The encoded protein, which belongs to the integrin beta chain family, plays an important role in the immune response. Integrins form a family of heterodimeric transmembrane receptors that regulate cell–adhesion and cell-extracellular matrix interactions. Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3, and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. ITGB2 is broadly expressed in bone marrow, appendix, and other tissues. Diseases associated with ITGB2 include Leukocyte Adhesion Deficiency, Type I, and Pertussis.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Related Pathways
Actin Dynamics Signaling Pathway
AKT Signaling Pathway
G Protein-coupled Receptors Signaling
MAPK-Erk Pathway
Autophagy Pathway
References
- Eich C, Lasonder E, Cruz LJ, et al. Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. Mattei F, ed. PLoS ONE. 2016;11(2):e0149637.
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- Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftmentAuthorMei, Y;Han, X;Liu, Y;Yang, J;Sumagin, R;Ji, P;Year2020JournalNat CommunApplicationexpressionPubMed ID: 32576838FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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