Sino Biological/Gremlin 1/GREM1 cDNA ORF Clone, Human, untagged/1/HG10632-UT
商品编号：
HG10632-UT
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Gremlin 1/GREM1 cDNA ORF Clone, Human, untagged: General Information
Gene
Species
Human
NCBI Ref Seq
NM_013372.5
RefSeq ORF Size
555 bp
Description
Full length Clone DNA of Human gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis).
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
Gremlin 1/GREM1 cDNA ORF Clone, Human, untagged: Synonyms
C15DUPq cDNA ORF Clone, Human; CKTSF1B1 cDNA ORF Clone, Human; CRAC1 cDNA ORF Clone, Human; CRCS4 cDNA ORF Clone, Human; DAND2 cDNA ORF Clone, Human; DRM cDNA ORF Clone, Human; DUP15q cDNA ORF Clone, Human; GREMLIN cDNA ORF Clone, Human; HMPS cDNA ORF Clone, Human; HMPS1 cDNA ORF Clone, Human; IHG-2 cDNA ORF Clone, Human; MPSH cDNA ORF Clone, Human; PIG2 cDNA ORF Clone, Human
Gremlin 1/GREM1 Background Information
GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon.
Full Name
gremlin 1, DAN family BMP antagonist
References
- Dimitrov BI, et al. (2010) Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome and Cenani--Lenz-like non-syndromic oligosyndactyly. J Med Genet. 47(8):569-74.
- Heron M, et al. (2011) Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis. Tissue Antigens. 77(2):112-7.
- van Vlodrop IJ, et al. (2010) Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol. 176(2):575-84.
Gremlin 1/GREM1 cDNA ORF Clone, Human,Related Products
- Gremlin 1/GREM1 cDNA ORF Clone, Human, N-His tagHG10632-NH
- Gremlin 1/GREM1 cDNA ORF Clone, Human, N-Myc tagHG10632-NM
- Gremlin 1/GREM1 cDNA ORF Clone, Human, N-HA tagHG10632-NY
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-Myc tagHG10632-CM
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-HA tagHG10632-CY
- Gremlin 1/GREM1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG10632-ACGLN
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-OFPSpark® tagHG10632-ACR
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-His tagHG10632-CH
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-GFPSpark® tagHG10632-ACG
- Gremlin 1/GREM1 cDNA ORF Clone in Cloning Vector, HumanHG10632-G
- Gremlin 1/GREM1 cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tagHG10632-NF
- Gremlin 1/GREM1 cDNA ORF Clone, Human, C-DYKDDDDK (Flag®) tagHG10632-CF
- Human Gremlin 1/GREM1 qPCR Primer PairHP100608
Gremlin 1/GREM1 cDNA ORF Clone, Mouse,Related Products
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-DYKDDDDK (Flag®) tagMG50016-CF
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, N-Myc tagMG50016-NM
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, N-DYKDDDDK (Flag®) tagMG50016-NF
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, N-HA tagMG50016-NY
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-OFPSpark® tagMG50016-ACR
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-His tagMG50016-CH
- Gremlin 1/GREM1 cDNA ORF Clone in Cloning Vector, MouseMG50016-M
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, untaggedMG50016-UT
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50016-ACG
- Gremlin 1/GREM1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50016-ACGLN
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-Myc tagMG50016-CM
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, C-HA tagMG50016-CY
- Gremlin 1/GREM1 cDNA ORF Clone, Mouse, N-His tagMG50016-NH
- Mouse Gremlin 1/GREM1 qPCR Primer PairMP200016
- Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancerAuthorPark, SA;Sung, NJ;Choi, BJ;Kim, W;Kim, SH;Surh, YJ;Year2020JournalBr. J. CancerApplicationexpressionPubMed ID: 32572171FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
