Sino Biological/DNMT1 cDNA ORF Clone, Human, untagged/1/HG11494-UT
商品编号：
HG11494-UT
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
DNMT1 cDNA ORF Clone, Human, untagged: General Information
Gene
Species
Human
NCBI Ref Seq
NM_001130823.1
RefSeq ORF Size
4899 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1389 A/G and 1782 A/G not causing the amino acid variation.
Description
Full length Clone DNA of Human DNA.(cytosine-5-)-methyltransferase 1.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Restriction Sites
KpnI + NotI (6.1kb + 4.9kb)
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
DNMT1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
DNMT1 cDNA ORF Clone, Human, untagged: Validated Images
DNMT1 cDNA ORF Clone, Human, untagged: Synonyms
ADCADN cDNA ORF Clone, Human; AIM cDNA ORF Clone, Human; CXXC9 cDNA ORF Clone, Human; DNMT cDNA ORF Clone, Human; HSN1E cDNA ORF Clone, Human; MCMT cDNA ORF Clone, Human
DNMT1 Background Information
DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein Dnmt3L. in addition to its DNA methylating activity, DNMT1 can act on gene transcription by modulating permissive H3K4 and repressive H3K27 trimethylation in developing inhibitory interneurons similar to what was found in other cell types. In particular, the transcriptional control of Pak6 was accomplished by interactions of DNMT1 with the Polycomb-repressor complex 2 (PCR2) core enzyme EZH2, mediating repressive H3K27 trimethylation at regulatory regions of the Pak6 gene locus. DNMT1 in promoting interneuron migration through the transcriptional control over key genes like Pak6 achieved by a crosstalk with histone tail methylation.
Full Name
DNA (cytosine-5-)-methyltransferase 1
Research Areas
- DNA methyltransferases (DNMTs)
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- Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1AuthorZhang, S;Li, J;Li, J;Yang, Y;Kang, X;Li, Y;Wu, X;Zhu, Q;Zhou, Y;Hu, Y;Year2018JournalSci RepApplicationexpressionPubMed ID: 29717211FoldedExpand
- DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolismAuthorMaresca, A;Del Dotto, V;Capristo, M;Scimonelli, E;Tagliavini, F;Morandi, L;Tropeano, CV;Caporali, L;Mohamed, S;Roberti, M;Scandiffio, L;Zaffagnini, M;Rossi, J;Cappelletti, M;Musiani, F;Contin, M;Riva, R;Liguori, R;Pizza, F;La Morgia, C;Antelmi, E;Polosa, PL;Mignot, E;Zanna, C;Plazzi, G;Carelli, V;Year2020JournalHum. Mol. Genet.ApplicationtemplatePubMed ID: 31984424FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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