Sino Biological/COMP cDNA ORF Clone, Human, C-HA tag/1/HG10173-CY
商品编号：
HG10173-CY
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
COMP cDNA ORF Clone, Human, C-HA tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_000095.2
RefSeq ORF Size
2316 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human cartilage oligomeric matrix protein with C terminal HA tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-HA
Restriction Sites
HindIII + NotI(6kb+2.32kb)
Tag Sequence
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
COMP cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
COMP cDNA ORF Clone, Human, C-HA tag: Validated Images
COMP cDNA ORF Clone, Human, C-HA tag: Synonyms
EDM1 cDNA ORF Clone, Human; EPD1 cDNA ORF Clone, Human; MED cDNA ORF Clone, Human; PSACH cDNA ORF Clone, Human; THBS5 cDNA ORF Clone, Human
COMP Background Information
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.
Full Name
cartilage oligomeric matrix protein
References
- Posey KL, et al. (2004) Role of TSP-5/COMP in pseudoachondroplasia. Int J Biochem Cell Biol. 36(6): 1005-12.
- Chen FH, et al. (2005) Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 282(34): 24591-8.
- Posey KL, et al. (2008) The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr Drug Targets. 9(10): 869-77.
- Tan K, et al. (2009) The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 23(8): 2490-501.
COMP cDNA ORF Clone, Human,Related Products
- COMP cDNA ORF Clone, Human, C-GFPSpark® tagHG10173-ACG
- COMP cDNA ORF Clone, Human, C-His tagHG10173-CH
- COMP cDNA ORF Clone, Human, C-OFPSpark® tagHG10173-ACR
- COMP cDNA ORF Clone, Human, N-His tagHG10173-NH
- COMP cDNA ORF Clone, Human, N-Myc tagHG10173-NM
- COMP Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG10173-ACGLN
- COMP cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tagHG10173-NF
- COMP cDNA ORF Clone, Human, N-HA tagHG10173-NY
- COMP cDNA ORF Clone in Cloning Vector, HumanHG10173-M
- COMP cDNA ORF Clone, Human, untaggedHG10173-UT
- COMP cDNA ORF Clone, Human, C-Myc tagHG10173-CM
- COMP cDNA ORF Clone, Human, C-DYKDDDDK (Flag®) tagHG10173-CF
- Human COMP qPCR Primer PairHP100241
- A variant in SMOC2, inhibiting BMP signaling by competitively binding to BMPR1B, causes multiple epiphyseal dysplasiaAuthorLong, F;Li, L;Shi, H;Li, P;Guo, S;Ma, Y;Li, Y;Wei, S;Year2020JournalBioRxivApplicationtransfectionFoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
