HuR/Elav-like RNA binding protein 1 (ELAVL1) positively regulates mRNA stability of AU-rich elements (ARE)-containing transcript such as pro-inflammatory cytokines. Ribotoxic stresses can trigger the production of pro-inflammatory mediators by enhancing mRNA stability and transcriptional activity. We investigated the effects of ribotoxin deoxynivalenol (DON) on HuR translocation and its involvement in the regulation of the pro-inflammatory interleukin-8 (IL-8) mR. ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress. ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress. EIF5A2, eukaryotic translation initiation factor 5A2, is associated with several human cancers. Overexpression of EIF5A2 was an independent predictor for poor metastasis-free survival of localized invasive BC patients treated with radical cystectomy. eIF5A2 is overexpressed by gene amplification or hypoxia in ESCCs, and associated with up-regulation of HIF1alpha, metastasis, and shorter survival times of patients. Increased expression of eIF5A2 increases metastasis and angiogenesis in ESCC via the HIF1alpha-mediated signaling pathway.

ELAV like RNA binding protein 1