Sino Biological/PPME1 cDNA ORF Clone in Cloning Vector, Human/1/HG29687-U
商品编号：
HG29687-U
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PPME1 cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_016147.2
RefSeq ORF Size
1161 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human protein phosphatase methylesterase 1
Plasmid
Vector
pUC19 Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
PPME1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PPME1 cDNA ORF Clone in Cloning Vector, Human: Synonyms
PME-1 cDNA ORF Clone, Human
PPME1 Background Information
Protein phosphatase methylesterase 1 (PPME1) is a protein phosphatase 2A (PP2A)-specific methylesterase that negatively regulates PP2A through demethylation at its carboxy-terminal leucine 309 residues. Emerging evidence shows that the upregulation of PPME1 is associated with poor prognosis in glioblastoma patients. Protein phosphatase methylesterase 1 has been identified as a novel gene in skeletal muscle that is upregulated in response to neurogenic atrophy in mice. Western blot analysis confirms that Ppme1 is expressed during both muscle cell proliferation and differentiation. Additionally, the Ppme1 promoter is active in muscle cells, while mutation of a conserved E-box element prevents full induction of the Ppme1 reporter gene, suggesting that Ppme1 is transcriptionally regulated by myogenic regulatory factors. PPME1 could be an attractive therapeutic target for a subset of gastric cancers (GCs) and lung cancers (LCs).
Full Name
protein phosphatase methylesterase 1
References
- Li J, et al. (2014) Genetic amplification of ppme1 in gastric and lung cancer and its potential as a novel therapeutic target. Cancer Biol Ther 15 (1): 128-134.
- Labuzan SA, et al. (2020) Inhibition of protein phosphatase methylesterase 1 dysregulates map kinase signaling and attenuates muscle cell differentiation. Gene 739 144515.
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- Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2AAuthorSvarcbahs, R;Jäntti, M;Kilpeläinen, T;Julku, UH;Urvas, L;Kivioja, S;Norrbacka, S;Myöhänen, TT;Year2019JournalPharmacol. Res.Applicationexpression and templatePubMed ID: 31759088FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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