Sino Biological/PU.1/SPI1 cDNA ORF Clone in Cloning Vector, Human/1/HG17186-G
商品编号：
HG17186-G
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PU.1/SPI1 cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_003120.2
RefSeq ORF Size
813 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human Spi-1 proto-oncogene.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
PU.1/SPI1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PU.1/SPI1 cDNA ORF Clone in Cloning Vector, Human: Synonyms
OF cDNA ORF Clone, Human; PU.1 cDNA ORF Clone, Human; SFPI1 cDNA ORF Clone, Human; SPI-1 cDNA ORF Clone, Human; SPI-A cDNA ORF Clone, Human
PU.1/SPI1 Background Information
SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a -17-kb upstream regulatory region and a promoter region. The E26 transformation-specific (ETS) family transcription factor PU.1/Spi1 acts as a master regulator of myeloid and lymphoid development. PU.1-deficient mice show a complete loss of microglia, indicating that PU.1 plays a pivotal role in micro-gliogenesis. The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells. The deregulation of its expression or activity contributes to leukemia, in which Spi1 can be either an oncogene or a tumor suppressor.
Full Name
spleen focus forming virus (SFFV) proviral integration oncogene
References
- Ungerbäck J, et al. (2018) Pioneering, chromatin remodeling, and epigenetic constraint in early t-cell gene regulation by spi1 (pu.1). Genome Res 28 (10): 1508-1519.
- Satoh J, et al. (2014) A comprehensive profile of chip-seq-based pu.1/spi1 target genes in microglia. Gene Regul Syst Bio 8 127-139.
- Goyal S, et al. (2017) Runx1 induces DNA replication independent active DNA demethylation at spi1 regulatory regions. BMC Mol Biol 18 (1): 9.
- Delestré L, et al. (2017) Senescence is a spi1-induced anti-proliferative mechanism in primary hematopoietic cells. Haematologica 102 (11): 1850-1860.
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- Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expressionAuthorZhang, K;Lv, DW;Li, R;Year2019JournalVirologyApplicationtemplatPubMed ID: 31743858FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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