Sino Biological/Human alk5 qPCR Primer Pair/1/HP100487
商品编号：
HP100487
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Human alk5 qPCR Primer Pair: General Information
Target Details
Species:
Human
NCBI RefSeq:
NM_001130916.2, NM_001306210.1, NM_004612.3
PCR Size:
161bp
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃.The suspended product is stable for six months from date of receipt when stored at -20℃.
***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI"s proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***
Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
Human alk5 qPCR Primer Pair: Synonyms
AAT5 qPCR Primer Pairs, Human; ACVRLK4 qPCR Primer Pairs, Human; ALK-5 qPCR Primer Pairs, Human; ALK5 qPCR Primer Pairs, Human; ESS1 qPCR Primer Pairs, Human; LDS1 qPCR Primer Pairs, Human; LDS1A qPCR Primer Pairs, Human; LDS2A qPCR Primer Pairs, Human; MSSE qPCR Primer Pairs, Human; SKR4 qPCR Primer Pairs, Human; tbetaR-I qPCR Primer Pairs, Human; TGFR-1 qPCR Primer Pairs, Human
alk5 Background Information
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and TGFB receptor subfamily. TGFBR1 / ALK-5 is found in all tissues examined. It is most abundant in placenta and least abundant in brain and heart. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. On ligand binding, TGFBR1 / ALK-5 forms a receptor complex consisting of two type I I and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto-phosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta signaling via TGFBR1 / ALK-5 is not required in myocardial cells during mammalian cardiac development, but plays an irreplaceable cell-autonomous role regulating cellular communication, differentiation and proliferation in endocardial and epicardial cells. Defects in TGFBR1 / ALK-5 are the cause of Loeys-Dietz syndrome type 1A (LDS1A), Loeys-Dietz syndrome type 2A (LDS2A), and aortic aneurysm familial thoracic type 5 (AAT5).
Full Name
transforming growth factor, beta receptor 1
References
- Seki T, et al. (2006) Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest. 86(2): 116-29. et al.
- Piek E, et al. (1999) TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci. 112 (24): 4557-68. et al.
- Dudas M, et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 266(1): 96-108.
alk5 qPCR Primer Pairs, Human, Related Products
- alk5 cDNA ORF Clone, Human, C-His tagHG10459-CH
- alk5 cDNA ORF Clone, Human, untaggedHG10459-UT
- alk5 cDNA ORF Clone, Human, C-HA tagHG10459-CY
- alk5 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG10459-ACGLN
- alk5 cDNA ORF Clone, Human, N-HA tagHG10459-NY
- alk5 cDNA ORF Clone, Human, C-Myc tagHG10459-CM
- alk5 cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tagHG10459-NF
- alk5 cDNA ORF Clone, Human, N-His tagHG10459-NH
- alk5 cDNA ORF Clone, Human, C-OFPSpark® tagHG10459-ACR
- alk5 cDNA ORF Clone, Human, C-DYKDDDDK (Flag®) tagHG10459-CF
- alk5 cDNA ORF Clone, Human, N-Myc tagHG10459-NM
- alk5 cDNA ORF Clone, Human, C-GFPSpark® tagHG10459-ACG
- alk5 cDNA ORF Clone in Cloning Vector, HumanHG10459-M
alk5 qPCR Primer Pairs, Mouse, Related Products
- alk5 cDNA ORF Clone, Mouse, C-Myc tagMG50238-CM
- alk5 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50238-ACGLN
- alk5 cDNA ORF Clone, Mouse, N-DYKDDDDK (Flag®) tagMG50238-NF
- alk5 cDNA ORF Clone, Mouse, C-OFPSpark® tagMG50238-ACR
- alk5 cDNA ORF Clone, Mouse, N-HA tagMG50238-NY
- alk5 cDNA ORF Clone, Mouse, untaggedMG50238-UT
- alk5 cDNA ORF Clone in Cloning Vector, MouseMG50238-M
- alk5 cDNA ORF Clone, Mouse, C-His tagMG50238-CH
- alk5 cDNA ORF Clone, Mouse, C-HA tagMG50238-CY
- alk5 cDNA ORF Clone, Mouse, N-His tagMG50238-NH
- alk5 cDNA ORF Clone, Mouse, N-Myc tagMG50238-NM
- alk5 cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50238-ACG
- alk5 cDNA ORF Clone, Mouse, C-DYKDDDDK (Flag®) tagMG50238-CF
alk5 qPCR Primer Pairs, Canine, Related Products
- alk5 cDNA ORF Clone, Canine, C-OFPSpark® tagDG70047-ACR
- alk5 cDNA ORF Clone, Canine, C-HA tagDG70047-CY
- alk5 cDNA ORF Clone, Canine, untaggedDG70047-UT
- alk5 cDNA ORF Clone, Canine, C-Myc tagDG70047-CM
- alk5 Lentiviral cDNA ORF Clone, Canine, C-GFPSpark® tagDG70047-ACGLN
- alk5 cDNA ORF Clone, Canine, N-His tagDG70047-NH
- alk5 cDNA ORF Clone, Canine, C-His tagDG70047-CH
- alk5 cDNA ORF Clone, Canine, C-GFPSpark® tagDG70047-ACG
- alk5 cDNA ORF Clone, Canine, N-HA tagDG70047-NY
- alk5 cDNA ORF Clone, Canine, C-DYKDDDDK (Flag®) tagDG70047-CF
- alk5 cDNA ORF Clone in Cloning Vector, CanineDG70047-G
- alk5 cDNA ORF Clone, Canine, N-DYKDDDDK (Flag®) tagDG70047-NF
- alk5 cDNA ORF Clone, Canine, N-Myc tagDG70047-NM
- PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c UpregulationAuthorChoi, HI;Park, JS;Kim, DH;Kim, CS;Bae, EH;Ma, SK;Kim, SW;Year2019JournalInt J Mol SciApplicationPCRPubMed ID: 31614978FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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