Sino Biological/NDUFS2 cDNA ORF Clone, Human, C-GFPSpark® tag/1/HG16895-ACG
商品编号：
HG16895-ACG
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NDUFS2 cDNA ORF Clone, Human, C-GFPSpark® tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_004550.4
RefSeq ORF Size
2121 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) with C terminal GFPSpark tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-GFPSpark®
Restriction Sites
HindIII + NotI(6kb+2.12kb)
Tag Sequence
GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
NDUFS2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
NDUFS2 cDNA ORF Clone, Human, C-GFPSpark® tag: Validated Images
The plasmid was transfected into 293FT adherent cells with Sinofection reagent (Cat#STF01) transiently. After 48 h, the fluorescent signals can be detected by fluorescence microscope. Green excitation 475/40nm, emission 535/45nm. Red excitation 560/55nm, emission 645/45nm. Orange excitation 525/45nm, emission 595/60nm
NDUFS2 cDNA ORF Clone, Human, C-GFPSpark® tag: Synonyms
CI-49 cDNA ORF Clone, Human
NDUFS2 Background Information
NDUFS2 (NADH: Ubiquinone Oxidoreductase Core Subunit S2) is a Protein Coding gene. The NDUFS2 gene, located on 1q23.3, is conserved in chimpanzee, Rhesus monkey, dog, and cow, etc. NDUFS2 belongs to the complex I 49 kDa subunit family. The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). The NDUFS2 protein is part of complex I of many pro-and eukaryotes. The nuclear gene coding for this protein is therefore an important candidate for mutational detection studies in enzymatic complex I deficient patients. Diseases associated with NDUFS2 include Mitochondrial Complex I Deficiency, Nuclear Type 6, and Leigh Syndrome With Cardiomyopathy. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Full Name
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
References
- Loeffen J, et al. (2001) Mutations in the complex i ndufs2 gene of patients with cardiomyopathy and encephalomyopathy. Ann Neurol 49 (2): 195-201.
- Liu L, et al. (2019) S100a4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex i protein ndufs2. J Biol Chem 294 (18): 7516-7527.
- Gerber S, et al. (2017) Compound heterozygosity for severe and hypomorphic ndufs2 mutations cause non-syndromic lhon-like optic neuropathy. J Med Genet 54 (5): 346-356.
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- S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2AuthorLiu, L;Qi, L;Knifley, T;Piecoro, DW;Rychahou, P;Liu, J;Mitov, MI;Martin, J;Wang, C;Wu, J;Weiss, HL;Butterfield, DA;Evers, BM;O"Connor, KL;Chen, M;Year2019JournalJ. Biol. Chem.ApplicationexpressionPubMed ID: 30885944FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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