Sino Biological/IL-6R cDNA ORF Clone in Cloning Vector, Human/1/HG10398-M
商品编号：
HG10398-M
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL-6R cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_000565.2
RefSeq ORF Size
1407 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human interleukin 6 receptor, transcript variant 1.
Plasmid
Vector
pMD18-T Simple Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
IL-6R cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
IL-6R cDNA ORF Clone in Cloning Vector, Human: Synonyms
CD126 cDNA ORF Clone, Human; gp80 cDNA ORF Clone, Human; IL-6R cDNA ORF Clone, Human; IL-6R-1 cDNA ORF Clone, Human; IL-6RA cDNA ORF Clone, Human; IL6Q cDNA ORF Clone, Human; IL6RA cDNA ORF Clone, Human; IL6RQ cDNA ORF Clone, Human
IL-6R Background Information
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called "trans-signaling" mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interleukin 6 receptor
Research Areas
- Neuroinflammation
Related Pathways
AKT Signaling Pathway
Jak-Stat Signaling Pathway
Autophagy Pathway
References
- Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
- Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
IL-6R cDNA ORF Clone, Human,Related Products
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- IL-6R cDNA ORF Clone, Human, C-OFPSpark® tagHG10398-ACR
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- Human IL-6R qPCR Primer PairHP100045
IL-6R cDNA ORF Clone, Mouse,Related Products
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- IL-6R cDNA ORF Clone in Cloning Vector, MouseMG50280-M
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- IL-6R cDNA ORF Clone, Mouse, C-DYKDDDDK (Flag®) tagMG50280-CF
- IL-6R cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50280-ACG
- IL-6R cDNA ORF Clone, Mouse, N-HA tagMG50280-NY
- IL-6R cDNA ORF Clone, Mouse, N-His tagMG50280-NH
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- Mouse IL-6R qPCR Primer PairMP200304
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IL-6R cDNA ORF Clone, Rhesus,Related Products
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- IL-6R cDNA ORF Clone, Rhesus, C-His tagCG90324-CH
- IL-6R cDNA ORF Clone, Rhesus, C-HA tagCG90324-CY
- IL-6R cDNA ORF Clone in Cloning Vector, RhesusCG90324-G
- IL-6R cDNA ORF Clone, Rhesus, C-OFPSpark® tagCG90324-ACR
- IL-6R cDNA ORF Clone, Rhesus, untaggedCG90324-UT
- IL-6R cDNA ORF Clone, Rhesus, C-GFPSpark® tagCG90324-ACG
- IL-6R cDNA ORF Clone, Rhesus, N-His tagCG90324-NH
- IL-6R cDNA ORF Clone, Rhesus, N-Myc tagCG90324-NM
- IL-6R cDNA ORF Clone, Rhesus, C-Myc tagCG90324-CM
- IL-6R Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tagCG90324-ACGLN
IL-6R cDNA ORF Clone, Canine,Related Products
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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