Sino Biological/NQO2 cDNA ORF Clone in Cloning Vector, Human/1/HG14634-G
商品编号：
HG14634-G
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NQO2 cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
BC006096
RefSeq ORF Size
696 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human NAD(P)H dehydrogenase, quinone 2.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
NQO2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
NQO2 cDNA ORF Clone in Cloning Vector, Human: Synonyms
DHQV cDNA ORF Clone, Human; DIA6 cDNA ORF Clone, Human; NMOR2 cDNA ORF Clone, Human; QR2 cDNA ORF Clone, Human
NQO2 Background Information
NQO2 is a 231 amino acid protein (25956 MW) that is 43 amino acids shorter than NQO1 at its carboxy-terminus. The human NQO2 cDNA and protein are 54 and 49% similar to the human liver cytosolic NQO1 cDNA and protein. NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone to hydroquinones. NQO2 catalyzes the metabolic reduction of quinones and provides protection against myelogenous hyperplasia and chemical carcinogenesis. Disruption of the NQO2 gene in mice leads to γ radiation-induced myeloproliferative diseases. NQO2 is involved in ROS generation and subsequent cytotoxicity in oocytes and its inhibition can restore oocyte maturation and embryo development, suggesting NQO2 as a pharmacological target for infertility cure.
Full Name
NAD(P)H dehydrogenase, quinone 2
References
- Xu J, et al. (2013) Nrh:Quinone oxidoreductase 2 (nqo2) protein competes with the 20 s proteasome to stabilize transcription factor ccaat enhancer-binding protein α (c/ebpα), leading to protection against γ radiation-induced myeloproliferative disease. J Biol Chem 288 (48): 34799-34808.
- Long DJ, 2nd, et al. (2000) Nrh:Quinone oxidoreductase2 (nqo2). Chem Biol Interact 129 (1-2): 99-112.
- Chen D, et al. (2017) Nqo2 inhibition relieves reactive oxygen species effects on mouse oocyte meiotic maturation and embryo development. Biol Reprod 97 (4): 598-611.
NQO2 cDNA ORF Clone, Human,Related Products
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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