Sino Biological/TUFM cDNA ORF Clone, Human, N-HA tag/1/HG16801-NY
商品编号：
HG16801-NY
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TUFM cDNA ORF Clone, Human, N-HA tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_003321.4
RefSeq ORF Size
1410 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human Tu translation elongation factor, mitochondrial with N terminal HA tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-N-HA
Restriction Sites
HindIII + XbaI(6kb+1.41kb)
Tag Sequence
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
TUFM cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
TUFM cDNA ORF Clone, Human, N-HA tag: Validated Images
TUFM cDNA ORF Clone, Human, N-HA tag: Synonyms
COXPD4 cDNA ORF Clone, Human; EF-TuMT cDNA ORF Clone, Human; EFTU cDNA ORF Clone, Human; P43 cDNA ORF Clone, Human
TUFM Background Information
The mitochondrial Elongation Factor Tu (EF-Tu), encoded by the TUFM gene, is a highly conserved GTPase, which is part of the mitochondrial protein translation machinery. In its activated form, it delivers the aminoacyl-tRNAs to the A site of the mitochondrial ribosome. TUFM, a key factor in the translational expression of mitochondrial DNA, plays an important role in the control of mitochondrial function. TUFM has been reported to be over-expressed in many tumor types including colorectal carcinoma (CRC) by proteomics. Increased expression of TUFM is a promising new prognostic indicator for colorectal carcinoma (CRC). Selective inhibition of TUFM in tumor cells may present a new avenue for the targeted therapy of this cancer. The TUFM is a novel regulator of epithelial-to-mesenchymal transition (EMT) and suggests a molecular link between mitochondrial dysfunction and EMT induction.
Full Name
Tu translation elongation factor, mitochondrial
References
- Shi H, et al. (2012) Tufm is a potential new prognostic indicator for colorectal carcinoma. Pathology 44 (6): 506-512.
- He K, et al. (2016) Tufm downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving ampk-gsk3β signaling. Cell Mol Life Sci 73 (10): 2105-2121.
- Di Nottia M, et al. (2017) Novel mutation in mitochondrial elongation factor ef-tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation. Biochim Biophys Acta Mol Basis Dis 1863 (4): 961-967.
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- The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune ResponsesAuthorWang, K;Ma, H;Liu, H;Ye, W;Li, Z;Cheng, L;Zhang, L;Lei, Y;Shen, L;Zhang, F;Year2019JournalCell RepApplicationexpressionPubMed ID: 31091447FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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