The cold-inducible RNA-binding motif protein 3 (RBM3) is involved in the protection of neurons in hypoxic-ischemic and neurodegenerative disorders. RBM3 belongs to a small group of proteins whose synthesis increases during hypothermia while global protein production is slowed down. RBM3 is a powerful neuroprotectant that inhibits neurodegenerative cell death in vivo and is a promising therapeutic target in brain ischemia. RBM3 is increased by the hormone fibroblast growth factor 21 (FGF21) in an age- and the temperature-dependent manner in rat cortical neurons. The multi-functional RNA-binding protein RBM3 is abundant in Neural stem cells (NSCs) and can be regulated by hypoxic exposure. RBM3 increases protein synthesis and confers cell protection in multiple cell types, has been identified as a possible regulator of skeletal muscle mass.

RNA binding motif (RNP1, RRM) protein 3