Sino Biological/COX-2 cDNA ORF Clone, Human, N-His tag/1/HG12036-NH
商品编号：
HG12036-NH
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
COX-2 cDNA ORF Clone, Human, N-His tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_000963
RefSeq ORF Size
1857 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) with N terminal His tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-SP-N-His
Restriction Sites
KpnI + XbaI(6kb+1.86kb)
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
COX-2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
COX-2 cDNA ORF Clone, Human, N-His tag: Validated Images
COX-2 cDNA ORF Clone, Human, N-His tag: Synonyms
COX-2 cDNA ORF Clone, Human; COX2 cDNA ORF Clone, Human; GRIPGHS cDNA ORF Clone, Human; hCox-2 cDNA ORF Clone, Human; PGG/HS cDNA ORF Clone, Human; PGHS-2 cDNA ORF Clone, Human; PHS-2 cDNA ORF Clone, Human
COX-2 Background Information
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
prostaglandin-endoperoxide synthase 2
Research Areas
- Neuroinflammation
- Cancer Drug Targets
Related Pathways
IL17 signaling pathway
References
- Picot, et al. (1994) The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367(6460):243-9.
- Xie W, et al. (1991) Expression of a Mitogen-Responsive Gene Encoding Prostaglandin Synthase is Regulated by mRNA Splicing. Proceedings of the National Academy of Sciences. 88(7):2692-6.
- Hla T, et al. (1992) Human Cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences. 89(16):7384-8.
COX-2 cDNA ORF Clone, Human,Related Products
- COX-2 cDNA ORF Clone, Human, C-GFPSpark® tagHG12036-ACG
- COX-2 cDNA ORF Clone, Human, untaggedHG12036-UT
- COX-2 cDNA ORF Clone, Human, N-OFPSpark® tagHG12036-ANR
- COX-2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG12036-ACGLN
- COX-2 cDNA ORF Clone, Human, C-Myc tagHG12036-CM
- COX-2 cDNA ORF Clone in Cloning Vector, HumanHG12036-G
- COX-2 cDNA ORF Clone, Human, C-His tagHG12036-CH
- COX-2 cDNA ORF Clone, Human, C-HA tagHG12036-CY
- COX-2 cDNA ORF Clone, Human, C-OFPSpark® tagHG12036-ACR
- COX-2 cDNA ORF Clone, Human, N-GFPSpark® tagHG12036-ANG
- COX-2 cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tagHG12036-NF
- COX-2 cDNA ORF Clone, Human, N-Myc tagHG12036-NM
- COX-2 cDNA ORF Clone, Human, N-HA tagHG12036-NY
- COX-2 cDNA ORF Clone, Human, C-DYKDDDDK (Flag®) tagHG12036-CF
- Human COX-2 qPCR Primer PairHP101570
- Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer"s DiseaseAuthorLee, JY;Han, SH;Park, MH;Baek, B;Song, IS;Choi, MK;Takuwa, Y;Ryu, H;Kim, SH;He, X;Schuchman, EH;Bae, JS;Jin, HK;Year2018JournalNat CommunApplicationexpressionPubMed ID: 29662056FoldedExpand
- N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer"s diseaseAuthorLee, JY;Han, SH;Park, MH;Song, IS;Choi, MK;Yu, E;Park, CM;Kim, HJ;Kim, SH;Schuchman, EH;Jin, HK;Bae, JS;Year2020JournalNat CommunPubMed ID: 32398649FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
