Sino Biological/YKL-40/CHI3L1 cDNA ORF Clone in Cloning Vector, Human/1/HG11227-M
商品编号：
HG11227-M
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
YKL-40/CHI3L1 cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_001276.2
RefSeq ORF Size
1152 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation 1092 T/C not causing the amino acid variation.
Description
Full length Clone DNA of Human chitinase 3-like 1 (cartilage glycoprotein-39).
Plasmid
Vector
pMD18-T Simple Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
YKL-40/CHI3L1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
YKL-40/CHI3L1 cDNA ORF Clone in Cloning Vector, Human: Synonyms
ASRT7 cDNA ORF Clone, Human; CGP-39 cDNA ORF Clone, Human; DKFZp686N19119 cDNA ORF Clone, Human; FLJ38139 cDNA ORF Clone, Human; GP-39 cDNA ORF Clone, Human; GP39 cDNA ORF Clone, Human; HC-gp39 cDNA ORF Clone, Human; hCGP-39 cDNA ORF Clone, Human; HCGP-3P cDNA ORF Clone, Human; YKL-40 cDNA ORF Clone, Human; YKL40 cDNA ORF Clone, Human; YYL-40 cDNA ORF Clone, Human
YKL-40/CHI3L1 Background Information
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.
Full Name
chitinase 3 like 1
References
- Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.
- Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67.
- Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87
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- CHI3L1 promotes tumor progression by activating TGF-β signaling pathway in hepatocellular carcinomaAuthorQiu, QC;Wang, L;Jin, SS;Liu, GF;Liu, J;Ma, L;Mao, RF;Ma, YY;Zhao, N;Chen, M;Lin, BY;Year2018JournalSci RepApplicationtemplatePubMed ID: 30301907FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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