Sino Biological/NF-kB p65 cDNA ORF Clone, Mouse, N-GFPSpark® tag/1/MG53057-ANG
商品编号：
MG53057-ANG
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
NF-kB p65 cDNA ORF Clone, Mouse, N-GFPSpark® tag: General Information
Gene
Species
Mouse
NCBI Ref Seq
NM_009045.4
RefSeq ORF Size
2379 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1869G/A,2310A/C not causing the amino acid variation.
Description
Full length Clone DNA of Mouse v-rel reticuloendotheliosis viral oncogene homolog A (avian) with N terminal GFPSpark tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-N-GFPSpark®
Restriction Sites
HindIII + NotI(6kb+2.38kb)
Tag Sequence
GFPSpark: GTGAGCAAGGGC……GAGCTGTACAAG
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
NF-kB p65 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
NF-kB p65 cDNA ORF Clone, Mouse, N-GFPSpark® tag: Validated Images
NF-kB p65 cDNA ORF Clone, Mouse, N-GFPSpark® tag: Synonyms
p65 cDNA ORF Clone, Mouse
NF-kB p65 Background Information
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
Full Name
v-rel avian reticuloendotheliosis viral oncogene homolog A
Research Areas
- Apoptosis Transcription Factors and Regulators
Related Pathways
Death Receptor Signaling
EGFR Signaling Pathway
NF-kB (NFkB) Pathway
TNF Signaling
B Cell Receptor Signaling Pathway
P38 MAPK Signaling Pathway
T Cell Receptor Signaling Pathway
IL1 signaling pathway
IL17 signaling pathway
References
- Hashimoto R, et al. (2011) Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology. 36(9): 1921-31.
- Vallabhapurapu S, et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 27: 693-733.
- Schmitz ML, et al. (2004) NF-kappaB: a multifaceted transcription factor regulated at several levels. Chembiochem. 5(10): 1348-58.
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- The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growthAuthorBowers, LW;Lineberger, CG;Ford, NA;Rossi, EL;Punjala, A;Camp, KK;Kimler, BK;Fabian, CJ;Hursting, SD;Year2018JournalBreast Cancer Res. Treat.ApplicationexpressionPubMed ID: 30367332FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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