Sino Biological/PD-1 cDNA ORF Clone, Human, untagged/1/HG10377-UT
商品编号：
HG10377-UT
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PD-1 cDNA ORF Clone, Human, untagged: General Information
Gene
Species
Human
NCBI Ref Seq
NM_005018.2
RefSeq ORF Size
867 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human programmed cell death 1 (PDCD1).
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Restriction Sites
HindIII + XbaI (6.1kb + 0.87kb)
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
PD-1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PD-1 cDNA ORF Clone, Human, untagged: Synonyms
CD279 cDNA ORF Clone, Human; hPD-1 cDNA ORF Clone, Human; hPD-l cDNA ORF Clone, Human; hSLE1 cDNA ORF Clone, Human; PD-1 cDNA ORF Clone, Human; PD1 cDNA ORF Clone, Human; SLEB2 cDNA ORF Clone, Human
PD-1 Background Information
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
- Cancer Immunotherapy
- Co-inhibitory Immune Checkpoint Targets
- Immune Checkpoint
- Immune Checkpoint Blockade: Blocking Antibodi
- Immune Checkpoint Blockade: PD1 / PDCD1 / CD2
- Immune Checkpoint Detection: Antibodies
- Immune Checkpoint Detection: ELISA Antibodies
- Immune Checkpoint Detection: IHC Antibodies
- Immune Checkpoint Detection: WB Antibodies
- Immune Checkpoint Proteins
- Immune Checkpoint Targets
- Immunotherapy
- PD1 / PDCD1 / CD279 Immune Checkpoint
- PD1 / PDCD1 / CD279 Immune Checkpoint Antibod
- PD1 / PDCD1 / CD279 Immune Checkpoint Protein
- Targeted Therapy
Full Name
programmed cell death 1
Research Areas
- ITIM/ITAM Immunoreceptors and Related Molecules
- Cancer Drug Targets
References
- James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
- Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
- del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
- Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
PD-1 cDNA ORF Clone, Human,Related Products
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- PD-1 cDNA ORF Clone, Human, N-His tagHG10377-NH
- PD-1 cDNA ORF Clone, Human, C-HA tagHG10377-CY
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- PD-1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG10377-ACGLN
- PD-1 cDNA ORF Clone in Cloning Vector, HumanHG10377-M
- PD-1 cDNA ORF Clone, Human, N-HA tagHG10377-NY
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- Human PD-1 qPCR Primer PairHP100412
PD-1 cDNA ORF Clone, Mouse,Related Products
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PD-1 cDNA ORF Clone, Rat,Related Products
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PD-1 cDNA ORF Clone, Canine,Related Products
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PD-1 cDNA ORF Clone, Rhesus,Related Products
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- Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patientsAuthorOsa, A;Uenami, T;Koyama, S;Fujimoto, K;Okuzaki, D;Takimoto, T;Hirata, H;Yano, Y;Yokota, S;Kinehara, Y;Naito, Y;Otsuka, T;Kanazu, M;Kuroyama, M;Hamaguchi, M;Koba, T;Futami, Y;Ishijima, M;Suga, Y;Akazawa, Y;Machiyama, H;Iwahori, K;Takamatsu, H;Nagatomo, I;Takeda, Y;Kida, H;Akbay, EA;Hammerman, PS;Wong, KK;Dranoff, G;Mori, M;Kijima, T;Kumanogoh, A;Year2018JournalJCI InsightApplicationexpressionPubMed ID: 30282824FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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