Sino Biological/Integrin beta 3 cDNA ORF Clone, Human, C-Myc tag/1/HG10787-CM
商品编号：
HG10787-CM
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Integrin beta 3 cDNA ORF Clone, Human, C-Myc tag: General Information
Gene
Species
Human
NCBI Ref Seq
NM_000212.2
RefSeq ORF Size
2412 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 1020A/G not causing the amino acid variation.
Description
Full length Clone DNA of Human integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-Myc
Restriction Sites
HindIII + XbaI(6kb+2.41kb)
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
Integrin beta 3 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Integrin beta 3 cDNA ORF Clone, Human, C-Myc tag: Validated Images
Integrin beta 3 cDNA ORF Clone, Human, C-Myc tag: Synonyms
BDPLT16 cDNA ORF Clone, Human; BDPLT2 cDNA ORF Clone, Human; CD61 cDNA ORF Clone, Human; GP3A cDNA ORF Clone, Human; GPIIIa cDNA ORF Clone, Human; GT cDNA ORF Clone, Human
Integrin beta 3 Background Information
ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. The ITGB3 protein product is the integrin beta chain beta 3. ITGB3 is broadly expressed in the thyroid, endometrium, and other tissues. Integrins containing the beta(3) subunit are key players in tumor growth and metastasis. ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer (CRC). ITGB3 is translationally activated in hypoxia and regulates malignant features, including epithelial-mesenchymal transition and cell migration, through the TGF-beta pathway, revealing a novel angle for the treatment of therapy-resistant hypoxic tumors. Bioinformatic algorithms and luciferase reporter assays revealed that integrin beta3 (ITGB3) is a direct target of miR-30a-5p. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16.
Full Name
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Research Areas
- ITIM/ITAM Immunoreceptors and Related Molecules
Related Pathways
Actin Dynamics Signaling Pathway
AKT Signaling Pathway
G Protein-coupled Receptors Signaling
MAPK-Erk Pathway
Autophagy Pathway
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- Irisin Mediates Effects on Bone and Fat via αV Integrin ReceptorsAuthorKim, H;Wrann, CD;Jedrychowski, M;Vidoni, S;Kitase, Y;Nagano, K;Zhou, C;Chou, J;Parkman, VA;Novick, SJ;Strutzenberg, TS;Pascal, BD;Le, PT;Brooks, DJ;Roche, AM;Gerber, KK;Mattheis, L;Chen, W;Tu, H;Bouxsein, ML;Griffin, PR;Baron, R;Rosen, CJ;Bonewald, LF;Spiegelman, BM;Year2018JournalCellPubMed ID: 30550785FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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