Sino Biological/Human FAP qPCR Primer Pair/1/HP101274
商品编号：
HP101274
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Human FAP qPCR Primer Pair: General Information
Target Details
Species:
Human
NCBI RefSeq:
NM_004460.3, NM_001291807.1
PCR Size:
97bp
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃.The suspended product is stable for six months from date of receipt when stored at -20℃.
***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI"s proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***
Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
Human FAP qPCR Primer Pair: Synonyms
DPPIV qPCR Primer Pairs, Human; DPPIVA qPCR Primer Pairs, Human; FAPA qPCR Primer Pairs, Human; Fapalpha qPCR Primer Pairs, Human; Fibroblast Activation Protein alpha qPCR Primer Pairs, Human; SIMP qPCR Primer Pairs, Human
FAP Background Information
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S9B family. Seprase / FAP is found in cell surface lamellipodia, invadopodia and on shed vesicles. Seprase / FAP appears to act as a proteolytically active 17-kDa dimer, consisting of two 97-kDa subunits. It is a member of the group type II integral serine proteases, which includes dipeptidyl peptidase IV ( DPPIV / CD26 ) and related type II transmembrane prolyl serine peptidases, which exert their mechanisms of action on the cell surface. Seprase / FAP colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Seprase / FAP colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. DPP4 and seprase exhibit multiple functions due to their abilities to form complexes with each other and to interact with other membrane-associated molecules. In association with DPP4, Seprase / FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. Seprase / FAP has a dual function in tumour progression. The proteolytic activity of Seprase has been shown to promote cell invasiveness towards the ECM and also to support tumour growth and proliferation. Seprase / FAP may have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
fibroblast activation protein, alpha
Research Areas
- Serine Proteases and Regulators
- Cancer Drug Targets
References
- Mori,Y.et al., 2004, Oncology. 67(5-6):411-9.
- AertgeertsK., et al., 2005, J. Biol. Chem. 280:19441-19444.
- LiuT., et al., 2005, J. Proteome Res. 4:2070-2080.
- GhersiG., et al., 2006, Cancer Res. 66:4652-4661.
- O"Brien,P.et al., 2008,Biochim Biophys Acta. 1784(9):1130-45.
FAP qPCR Primer Pairs, Human, Related Products
- FAP cDNA ORF Clone, Human, N-His tagHG10464-NH
- FAP Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tagHG10464-ACGLN
- FAP cDNA ORF Clone, Human, C-DYKDDDDK (Flag®) tagHG10464-CF
- FAP cDNA ORF Clone, Human, C-His tagHG10464-CH
- FAP cDNA ORF Clone, Human, C-Myc tagHG10464-CM
- FAP cDNA ORF Clone, Human, C-HA tagHG10464-CY
- FAP cDNA ORF Clone, Human, C-GFPSpark® tagHG10464-ACG
- FAP cDNA ORF Clone in Cloning Vector, HumanHG10464-M
- FAP cDNA ORF Clone, Human, N-Myc tagHG10464-NM
- FAP cDNA ORF Clone, Human, N-HA tagHG10464-NY
- FAP cDNA ORF Clone, Human, C-OFPSpark® tagHG10464-ACR
- FAP cDNA ORF Clone, Human, N-DYKDDDDK (Flag®) tagHG10464-NF
- FAP cDNA ORF Clone, Human, untaggedHG10464-UT
FAP qPCR Primer Pairs, Mouse, Related Products
- FAP Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50996-ACGLN
- FAP cDNA ORF Clone, Mouse, C-His tagMG50996-CH
- FAP cDNA ORF Clone in Cloning Vector, MouseMG50996-G
- FAP cDNA ORF Clone, Mouse, C-GFPSpark® tagMG50996-ACG
- FAP cDNA ORF Clone, Mouse, C-OFPSpark® tagMG50996-ACR
- FAP cDNA ORF Clone, Mouse, N-Myc tagMG50996-NM
- FAP cDNA ORF Clone, Mouse, C-HA tagMG50996-CY
- FAP cDNA ORF Clone, Mouse, untaggedMG50996-UT
- FAP cDNA ORF Clone, Mouse, N-DYKDDDDK (Flag®) tagMG50996-NF
- FAP cDNA ORF Clone, Mouse, N-HA tagMG50996-NY
- FAP cDNA ORF Clone, Mouse, N-His tagMG50996-NH
- FAP cDNA ORF Clone, Mouse, C-Myc tagMG50996-CM
- FAP cDNA ORF Clone, Mouse, C-DYKDDDDK (Flag®) tagMG50996-CF
FAP qPCR Primer Pairs, Cynomolgus, Related Products
- FAP cDNA ORF Clone in Cloning Vector, CynomolgusCG90879-G
- Fibroblast activating protein-α expression in squamous cell carcinoma of the esophagus in primary and irradiated tumors: the use of archival FFPE material for molecular techniquesAuthorTabola, R;Zaremba-Czogalla, M;Baczynska, D;Year2017JournalEuropean Journal of HistochemistryApplicationprimer for RT-PCRPubMed ID: 28735527FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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