Sino Biological/PIAS1 cDNA ORF Clone, Human, N-Myc tag/1/HG15957-NM
商品编号：
HG15957-NM
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
PIAS1 cDNA ORF Clone, Human, N-Myc tag: General Information
Gene
Species
Human
NCBI Ref Seq
BC121797
RefSeq ORF Size
1956 bp
Description
Full length Clone DNA of Human protein inhibitor of activated STAT, 1with N terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-N-Myc
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5" TAATACGACTCACTATAGGG 3" )BGH( 5" TAGAAGGCACAGTCGAGG 3" )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
PIAS1 cDNA ORF Clone, Human, N-Myc tag: Synonyms
DDXBP1 cDNA ORF Clone, Human; GBP cDNA ORF Clone, Human; GU/RH-II cDNA ORF Clone, Human; ZMIZ3 cDNA ORF Clone, Human
PIAS1 Background Information
Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) (PIAS1) was identified as a cellular protein binding to N. PIAS1 is known to bind to p65 (RelA) in the nucleus and blocks its DNA binding, thus functions as a repressor of NF-κB. Binding of N to PIAS1 released p65 for NF-κB activation. The N-terminal half of PIAS1 was mapped as the N-binding domain, and this region overlapped its p65-binding domain. For N, the region between 37 and 72 aa was identified as the binding domain to PIAS1, and this domain alone was able to activate NF-κB. PIAS1 is one of the few known SUMO E3 ligases. PIAS1 has been implicated in several biological processes including repression of innate immunity and DNA repair. PIAS1 is a key regulator of STAT1 signaling and may be implicated in carcinogenesis.
Full Name
protein inhibitor of activated STAT, 1
Related Pathways
p53 Pathway
Jak-Stat Signaling Pathway
Common G-Chain signaling pathway
References
- Ke H, et al. (2019) Interaction of pias1 with prrs virus nucleocapsid protein mediates nf-κb activation and triggers proinflammatory mediators during viral infection. Sci Rep 9 (1): 11042.
- Erb HHH, et al. (2019) Pias1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target. PLoS One 14 (10): e0224085.
- Constanzo JD, et al. (2016) Pias1 is essential for erythroid and vascular development in the mouse embryo. Dev Biol 415 (1): 98-110.
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- TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated SenescenceAuthorLi, K;Wang, F;Cao, WB;Lv, XX;Hua, F;Cui, B;Yu, JJ;Zhang, XW;Shang, S;Liu, SS;Yu, JM;Han, MZ;Huang, B;Zhang, TT;Li, X;Jiang, JD;Hu, ZW;Year2017JournalCancer CellPubMed ID: 28486108FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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