Sino Biological/IL21 cDNA ORF Clone in Cloning Vector, Mouse/1/MG50137-M
商品编号：
MG50137-M
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
IL21 cDNA ORF Clone in Cloning Vector, Mouse: General Information
Gene
Species
Mouse
NCBI Ref Seq
NM_021782.2
RefSeq ORF Size
441 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Mouse interleukin 21.
Plasmid
Vector
pMD18-T Simple Vector
Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
IL21 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
IL21 cDNA ORF Clone in Cloning Vector, Mouse: Synonyms
IL-21 cDNA ORF Clone, Mouse
IL21 Background Information
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
interleukin 21
Related Pathways
AKT Signaling Pathway
Jak-Stat Signaling Pathway
Autophagy Pathway
Common G-Chain signaling pathway
IL12 signaling pathway
References
- Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34.
- Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10.
- Parrish-Novak J, et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4 Kuchen S, et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9):5886-96.
IL21 cDNA ORF Clone, Human,Related Products
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IL21 cDNA ORF Clone, Mouse,Related Products
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IL21 cDNA ORF Clone, Rat,Related Products
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IL21 cDNA ORF Clone, Canine,Related Products
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IL21 cDNA ORF Clone, Rhesus,Related Products
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- IL21 cDNA ORF Clone, Rhesus, C-His tagCG90298-CH
- IL21 cDNA ORF Clone, Rhesus, untaggedCG90298-UT
- IL21 cDNA ORF Clone, Rhesus, C-Myc tagCG90298-CM
- IL21 cDNA ORF Clone in Cloning Vector, RhesusCG90298-G
- IL21 cDNA ORF Clone, Rhesus, N-HA tagCG90298-NY
- IL21 cDNA ORF Clone, Rhesus, C-DYKDDDDK (Flag®) tagCG90298-CF
- Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearanceAuthorShen, Z;Yang, H;Yang, S;Wang, W;Cui, X;Zhou, X;Liu, W;Pan, S;Liu, Y;Zhang, J;Zhang, J;Xie, Y;Liu, J;Year2017JournalNat CommunApplicationtemplatePubMed ID: 29242561FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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