Sino Biological/SP1 cDNA ORF Clone in Cloning Vector, Human/1/HG12024-G
商品编号：
HG12024-G
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
SP1 cDNA ORF Clone in Cloning Vector, Human: General Information
Gene
Species
Human
NCBI Ref Seq
NM_138473.2
RefSeq ORF Size
2358 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human Sp1 transcription factor.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
SP1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
SP1 cDNA ORF Clone in Cloning Vector, Human: Synonyms
TSFP1 cDNA ORF Clone, Human
SP1 Background Information
Sp1 (specificity protein 1) belongs to the 26 member strong Sp/KLF family of transcription factors. Sp1 is a well-known member of a family of transcription factors that also includes Sp2, Sp3, and Sp4, which are implicated in an ample variety of essentially biological processes and have been proven important in cell growth, differentiation, apoptosis, and carcinogenesis. Sp1 activates the transcription of many cellular genes that contain putative CG-rich Sp-binding sites in their promoters. Sp1 also has a role in the DNA damage response; at low levels of DNA damage, Sp1 is phosphorylated by ATM and localizes to double-strand break sites where it facilitates DNA double-strand break repair. Depletion of Sp1 increases the sensitivity of cells to DNA damage, whereas overexpression of Sp1 can drive cells into apoptosis. In response to a variety of stimuli, Sp1 can be regulated through proteolytic cleavage by caspases and/or degradation.
Full Name
Sp1 transcription factor
References
- Vizcaíno C, et al. (2015) Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacol Ther 152 111-124.
- Torabi B, et al. (2018) Caspase cleavage of transcription factor sp1 enhances apoptosis. Apoptosis 23 (1): 65-78.
- O"Connor L, et al. (2016) The role of the ubiquitously expressed transcription factor sp1 in tissue-specific transcriptional regulation and in disease. Yale J Biol Med 89 (4): 513-525.
- Beishline K, et al. (2015) Sp1 and the "hallmarks of cancer". Febs j 282 (2): 224-258.
SP1 cDNA ORF Clone, Human,Related Products
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- Human SP1 qPCR Primer PairHP101560
- MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1AuthorSingh, VP;Mathison, M;Patel, V;Sanagasetti, D;Gibson, BW;Yang, J;Rosengart, TK;Year2016JournalJ Am Heart AssocApplicationtemplateFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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