Sino Biological/TREM-2 Matched ELISA Antibody Pair Set,Human/1/SEK11084
商品编号：
SEK11084
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TREM-2 Matched ELISA Antibody Pair Set,Human General Information
Product name
TREM-2 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human TREM-2
Assay range
54.69-3500 pg/mL
Materials provided
1. Capture Antibody 1 mg/mL of mouse anti-Human TREM-2/TREM2 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 11084-R016)2. Detection Antibody 0.2 mg/mL of rabbit anti-Human TREM-2/TREM2 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 11084-MM08)3. Standard Each vial contains 100 ng of recombinant Human TREM-2/TREM2. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3500 pg/mL is recommended.
Product overview
This TREM-2 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human TREM-2 . It contains Human TREM-2 capture antibody, Human TREM-2 detector antibody (HRP)and a highly purifiedHEK293-expressedrecombinant Human TREM-2 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
TREM-2 Matched ELISA Antibody Pair Set,Human Images
TREM-2 Matched ELISA Antibody Pair Set,Human: Synonyms
TREM-2 Matched ELISA Antibody Pair Set, Human; Trem2a Matched ELISA Antibody Pair Set, Human; Trem2b Matched ELISA Antibody Pair Set, Human; Trem2c Matched ELISA Antibody Pair Set, Human
TREM-2 Background Information
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
Full Name
triggering receptor expressed on myeloid cells 2
References
- Bouchon,A. et al., 2000, J. Immunol. 164: 4991-4995.
- Paloneva,J. et al., 2002, Am. J. Hum. Genet. 71:656-662.
- Prada,I. et al., 2006, Neuroscience. 140(4): 1139-48.
- Neumann,H. et al., 2007, J Neuroimmunol. 184 (1-2): 92-9.
- Thrash,JC. et al., 2009, Neurochem Res. 34(1): 38-45.
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosisAuthorG Kleinberger, Y Yamanishi…Year2014JournalScience Translational MedicineApplicationELISAPubMed ID: 24990881FoldedExpand
- Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levelsAuthorFeng, JY;Su, WJ;Pan, SW;Yeh, YC;Lin, YY;Chen, NJ;Year2018JournalSci RepApplicationELISA (serum sample)PubMed ID: 29844416FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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