Sino Biological/TrkB Matched ELISA Antibody Pair Set,Human/1/SEK10047
商品编号：
SEK10047
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TrkB Matched ELISA Antibody Pair Set,Human General Information
Product name
TrkB Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human TrkB
Assay range
10.98-700 pg/mL
Materials provided
1. Capture Antibody 1 mg/mL of mouse anti-Human TrkB/NTRK2 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10047-MM12)2. Detection Antibody 0.2 mg/mL of mouse anti-Human TrkB/NTRK2 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.3 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10047-MM01)3. Standard Each vial contains 28 ng of recombinant Human TrkB/NTRK2. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 700 pg/mL is recommended.
Product overview
This TrkB Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human TrkB . It contains Human TrkB capture antibody, Human TrkB detector antibody (HRP)and a highly purifiedHEK293-expressedrecombinant Human TrkB protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.
TrkB Matched ELISA Antibody Pair Set,Human Images
TrkB Matched ELISA Antibody Pair Set,Human: Synonyms
GP145-TrkB Matched ELISA Antibody Pair Set, Human; GP145-TrkB/GP95-TrkB Matched ELISA Antibody Pair Set, Human; Tkrb Matched ELISA Antibody Pair Set, Human; trk-B Matched ELISA Antibody Pair Set, Human; TRKB Matched ELISA Antibody Pair Set, Human
TrkB Background Information
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
neurotrophic tyrosine kinase, receptor, type 2
Research Areas
- Receptor Tyrosine Kinases (RTKs)
- Cancer Drug Targets
References
- Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
- Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
- Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.
- Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissuesAuthorXiong, J;Zhou, L;Lim, Y;Yang, M;Zhu, YH;Year2015JournalOncologyLettersApplicationELISA for mature TrkB in tissue samplesPubMed ID: 26171003FoldedExpand
- ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependenceAuthorZhou, L;Xiong, J;Ruan, CS;Ruan, Y;Liu, D;Bao, JJ;Zhou, XF;Year2018JournalTransl PsychiatryApplicationELISA (serum)PubMed ID: 29520063FoldedExpand
If you couldn"t find the specific citation, you can:
- Find All Citations
- Submit a CitationGet a Publication Reward
- Leave Us a Message
品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
联络我们
