Sino Biological/GDF15 Protein, Human, Recombinant (Mature Form, His Tag)/1/10936-H07Y
商品编号：
10936-H07Y
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
GDF15 Protein, Human, Recombinant (Mature Form, His Tag): Product Information
Purity
> 90 % as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mature form of human GDF15 (NP_004855.2) (Ala197-Ile308) was expressed with a polyhistidine tag at the N-terminus.
Accession#
NP_004855.2
Expressed Host
Yeast
Species
Human
Predicted N Terminal
His
Molecule Mass
The recombinant mature form of human GDF15 consists of 122 amino acids and predicts a molecular mass of 13.7 kDa. As a result of glycosylation, it migrates as an approximately 18.2 kDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile 50mM HAc, pH 2.9.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
GDF15 Protein, Human, Recombinant (Mature Form, His Tag): Images
GDF15 Protein, Human, Recombinant (Mature Form, His Tag): Synonyms
GDF-15 Protein, Human; MIC-1 Protein, Human; MIC1 Protein, Human; NAG-1 Protein, Human; PDF Protein, Human; PLAB Protein, Human; PTGFB Protein, Human
GDF15 Background Information
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
Full Name
growth differentiation factor 15
References
- Ago T, et al. (2006) GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 98 (3): 294-297.
- Hsiao E, et al. (2000) Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 20 (10): 3742-51.
- Zimmers T, et al. (2005) Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury. Shock. 23 (6): 543-8.
Human GDF15 Proteins
- GDF15 Protein, Human, Recombinant (hFc Tag)10936-H01H
- Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes InterventionAuthorNakayasu, ES;Syed, F;Tersey, SA;Gritsenko, MA;Mitchell, HD;Chan, CY;Dirice, E;Turatsinze, JV;Cui, Y;Kulkarni, RN;Eizirik, DL;Qian, WJ;Webb-Robertson, BM;Evans-Molina, C;Mirmira, RG;Metz, TO;Year2020JournalCell Metab.Applicationcell-basedPubMed ID: 31928885FoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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