华生物/TNFR2/CD120b/TNFRSF1B中和抗体/1/10417-R00N6
商品编号：
10417-R00N6
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody General Information
Product name
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody
Validated applications
Neutralization
Species reactivity
Reacts with: Human
Specificity
Human TNFR2/TNFRSF1BNo cross-reactivity in ELISA withMouse TNFR2 (Catalog # 50128-M08H)
Immunogen
Recombinant Human TNFR2 protein (Catalog#10417-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human TNFRSF1B / CD120b (rh TNFRSF1B; Catalog#10417-H08H; Met 1-Asp 257; NP_001057.1).
Source
Monoclonal Rabbit IgG Clone #R00N6
Purification
Protein A
Formulation
0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Conjugate
Unconjugated
Endotoxin
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Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody Validated Applications
Notes
| Block： | In a functional ELISA which immobilized recombinant Human TNFR2 (Catalog# 10417-H08H) at 1 μg/mL (100 µL/well) in the plate, the Rabbit anti-Human TNFR2 Monoclonal Antibody (Catalog# 10417-R00N6) can block the binding of 2 μg/mL of biotinylated Human TNFα (Catalog# 10602-HNAE-B) to Human TNFR2 , the EC50 is 2.07 μg/mL . |
| Neutralization： | The neutralization activity of TNFR2/TNFRSF1B Neutralizing Antibody is Measured by its ability to neutralize TNFR2/TNFRSF1B-mediated inhibition of cytotoxicity in the L‑929 mouse fibroblast cell line. The Neutralization titer (IC50) is typically 1-3 µg/mL in the presence of 1 μg/mL Recombinant Human TNFR2/TNFRSF1B, 0.25 ng/mL Recombinant Human TNFa, and 1 µg/mL actinomycin D. |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody Images
TNFR2/TNFRSF1B-mediated inhibition of cytotoxicity was Neutralized by Human TNFR2 Antibody. Recombinant Human TNFR2/TNFRSF1B (Catalog # 0417-H08H) inhibits Recombinant Human TNFa (Catalog #10602-HNAE) induced cytotoxicity in the L-929 mouse fibroblast cell line. Inhibition of Recombinant Human TNFa (0.25 ng/mL) activity elicited by Recombinant Human TNFR2/TNFRSF1B (1 µg/mL) is neutralized by increasing concentrations of Human TNFR2/TNFRSF1B Monoclonal Antibody (Catalog # 0417-R00N6). The IC50 is typically 1-3 µg/mL in the presence of the metabolic inhibitor actinomycin D (1 µg/mL).
TNFR2 / CD120b / TNFRSF1B Neutralizing Antibody: Synonyms
Anti-CD120b Antibody; Anti-p75 Antibody; Anti-p75TNFR Antibody; Anti-TBPII Antibody; Anti-TNF-R-II Antibody; Anti-TNF-R75 Antibody; Anti-TNFBR Antibody; Anti-TNFR1B Antibody; Anti-TNFR2 Antibody; Anti-TNFR80 Antibody
TNFR2/TNFRSF1B Background Information
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
tumor necrosis factor receptor superfamily, member 1b
Research Areas
- Neuroinflammation
References
- Komata T, et al. (1999) Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens. 53(6): 527-33.
- Tsuchiya N, et al. (2001) Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun. 2(6): 317-22.
- Guo G, et al. (1999) Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 277(5): 766-72.
- The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effectAuthorNaserian, S;Abdelgawad, ME;Afshar Bakshloo, M;Ha, G;Arouche, N;Cohen, JL;Salomon, BL;Uzan, G;Year2020JournalCell Commun. SignalApplicationco-culturePubMed ID: 32546175FoldedExpand
- TNFα priming through its interaction with TNFR2 enhances Endothelial Progenitor Cell immunosuppressive effect: a new hope for their widespread clinical applicationAuthorBARKESTANI, MN;SHAMDANI, S;BAKSHLOO, MA;Year2020JournalResearch SquareApplicationblockingFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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