Sino Biological/Recombinant Anti-CD19 Antibody, Rabbit Monoclonal/1/11880-R109
商品编号：
11880-R109
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Recombinant Anti-CD19 Antibody, Rabbit Monoclonal General Information
Product name
Recombinant Anti-CD19 Antibody, Rabbit Monoclonal
Validated applications
IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CD19
Immunogen
Recombinant Human CD19 protein (Catalog#11880-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD19 (rh CD19; Catalog#11880-H08H; P15391-1; Met1-Lys291).
Source
Monoclonal Rabbit IgG Clone #109
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Recombinant Anti-CD19 Antibody, Rabbit Monoclonal Validated Applications
| Application | Dilution |
|---|---|
| IHC-P | 1:100-1:500 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Recombinant Anti-CD19 Antibody, Rabbit Monoclonal Images
Immunochemical staining CD19 in human tonsil with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of B cells.
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Immunochemical staining CD19 in human spleen (from 2 donors) with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of B cells.
Immunochemical staining CD19 in human spleen with rabbit monoclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Recombinant Anti-CD19 Antibody, Rabbit Monoclonal: Synonyms
Anti-B4 Antibody; Anti-CVID3 Antibody
CD19 Background Information
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in the threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell co-receptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.
- Cancer Immunotherapy
- Immune Checkpoint
- Immunotherapy
- Targeted Therapy
Full Name
CD19 molecule
Research Areas
- Cancer Drug Targets
Related Pathways
B Cell Receptor Signaling Pathway
References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.Science. 256 (5053): 105-7.
- Tumor-educated B cells promote renal cancer metastasis via inducing the IL-1β/HIF-2α/Notch1 signalsAuthorLi, S;Huang, C;Hu, G;Ma, J;Chen, Y;Zhang, J;Year2020JournalCell Death & DiseaseApplicationWBFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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