Sino Biological/Anti-IFNAR1 Antibody, Rabbit Polyclonal/1/50469-RP02
商品编号：
50469-RP02
品牌：
sinobiological
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Anti-IFNAR1 Antibody, Rabbit Polyclonal General Information
Product name
Anti-IFNAR1 Antibody, Rabbit Polyclonal
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse IFNAR1
Immunogen
Recombinant Mouse IFNAR-1 protein (Catalog#50469-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IFNAR-1 / CRF2-1 (rM IFNAR-1; Catalog#50469-M08H; NP_034638.2; Met 1-Thr 429). IFNAR-1 specific IgG was purified by mouse IFNAR-1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-IFNAR1 Antibody, Rabbit Polyclonal Validated Applications
| Application | Dilution |
|---|---|
| ELISA | 1:5000-1:10000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-IFNAR1 Antibody, Rabbit Polyclonal: Synonyms
Anti-CD118 Antibody; Anti-Ifar Antibody; Anti-Ifnar Antibody; Anti-Ifrc Antibody; Anti-Infar Antibody
IFNAR1 Background Information
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Full Name
interferon (alpha, beta and omega) receptor 1
References
- Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
- Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
- Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
- Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungsAuthorGui, J;Zahedi, F;Ortiz, A;Cho, C;Katlinski, K;Alicea-Torres, K;Li, J;Todd, L;Zhang, H;Beiting, D;Sander, C;Kirkwood, J;Snow, B;Wakeham, A;Mak, T;Diehl, J;Koumenis, C;Ryeom, S;Stanger, B;Puré, E;Gabrilovich, D;Fuchs, S;Year2020JournalNat CancerApplicationIFFoldedExpand
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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
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