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当前位置： 首页 > 产品中心 > peptide > Sino Biological/Anti-SerpinB3 Antibody, Rabbit Polyclonal/1/13218-T52
商品详细Sino Biological/Anti-SerpinB3 Antibody, Rabbit Polyclonal/1/13218-T52
Sino Biological/Anti-SerpinB3 Antibody, Rabbit Polyclonal/1/13218-T52
Sino Biological/Anti-SerpinB3 Antibody, Rabbit Polyclonal/1/13218-T52
商品编号： 13218-T52
品牌： sinobiological
市场价： ¥0.00
美元价： 0.00
产地： 美国(厂家直采)
公司：
产品分类： 多肽合成
公司分类： peptide
联系Q Q： 3392242852
电话号码： 4000-520-616
电子邮箱： info@ebiomall.com
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Anti-SerpinB3 Antibody, Rabbit Polyclonal General Information

Product name
Anti-SerpinB3 Antibody, Rabbit Polyclonal
Validated applications
WB,ELISA,IP
Species reactivity
Reacts with: Human
Specificity
Human SerpinB3
Immunogen
Recombinant Human SERPINB3 / SCCA-1 protein (Catalog#13218-H07B)
Preparation
Produced in rabbits immunized with purified, recombinant Human SERPINB3 / SCCA-1 (rh SERPINB3 / SCCA-1; Catalog#13218-H07B; AAB20405.1; Asn2-Pro390). SERPINB3 / SCCA-1 specific IgG was purified by Human SERPINB3 / SCCA-1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SerpinB3 Antibody, Rabbit Polyclonal Validated Applications

ApplicationDilution
WB1:500-1:1000
ELISA1:25000-1:50000
IP 0.2-1 μL/mg of lysate
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SerpinB3 Antibody, Rabbit Polyclonal Images

Human SERPINB3 / SCCA-1 Western blot (WB) 13542

Anti-SERPINB3(2-390) rabbit polyclonal antibody at 1:500 dilution

Lane A: A431 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800)at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:45 kDa

Observed band size:42 kDa

(We are unsure as to the identity of these extra bands.)

Human SERPINB3 / SCCA-1 Immunoprecipitation(IP) 15298

SERPINB3 was immunoprecipitated using:

Lane A:0.5 mg A431 Whole Cell Lysate

0.5 µL anti-SERPINB3 rabbit polyclonal antibody and 15 μl of50 %Protein G agarose.

Primary antibody:

Anti-SERPINB3 rabbit polyclonal antibody,at 1:500 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 43 kDa

Observed band size: 43 kDa

Anti-SerpinB3 Antibody, Rabbit Polyclonal: Synonyms

Anti-HsT1196 Antibody; Anti-SCC Antibody; Anti-SCCA-1 Antibody; Anti-SCCA-PD Antibody; Anti-SCCA1 Antibody; Anti-T4-A Antibody

SerpinB3 Background Information

SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.
Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 3
Research Areas
  • Serine Proteases and Regulators
References
  • Schneider SS, et al. (1995) A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci. 92(8):3147-51.
  • Suminami Y, et al.. (1992) Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun. 181(1):51-8.
  • Mino-Miyagawa N, et al. (1990) Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus. Cancer. 66(7):1505-12.
  • Anti-SerpinB3 Antibody
    【Rabbit】【Monoclonal】【IP】
    13218-R018
  • Anti-SerpinB3 Antibody
    【Rabbit】【Polyclonal】【ELISA】
    13218-RP01
  • Anti-SerpinB3 Antibody
    【Mouse】【Monoclonal】【WB,ELISA】
    13218-MM13
  • Anti-SerpinB3 Antibody
    【Rabbit】【Polyclonal】【IHC-P,ICC/IF】
    204174-T10
  • The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study
    Author
    Ye, S;Sun, X;Kang, B;Wu, F;Zheng, Z;Xiang, L;Lesénéchal, M;Heskia, F;Liang, J;Yang, H;
    Year
    2020
    Journal
    BMC Cancer
    PubMed ID: 32085736FoldedExpand

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品牌介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000 种，包括超过 3,800 种人源细胞表达重组蛋白产品，能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求；公司还能提供约 12,000 种抗体，其中单克隆抗体数量约 4,600 种，能够覆盖生命科学研究的多个领域，为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供「一站式」生物试剂产品和技术服务。义翘神州的客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。目前公司已经在美国、欧洲建立了子公司，已成为生物试剂行业国内领先的科技公司之一。
公司介绍
北京义翘神州科技股份有限公司（Sino Biological Inc.）是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务。义翘神州为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过 4.6 万种，其中重组蛋白约 6,000
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Elisa试剂盒试剂 蛋白质试剂 抗体试剂 Gene Reagent
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